6 Dabigatran Etexilate Lecture Notes For Healthcare Professionals

1. Trade names:

  • Pradaxa

2. It is a Direct Oral AntiCoagulant (DOAC) that targets thrombin.

3. Its renal clearance is about 85%.

4. The half-life of Dabigatran is about 12-17 hours

5. Dabigatran is approved by the FDA in the following conditions:

  • Prophylaxis against embolic events especially stroke in Atrial Fibrillation (AF), the dose will be 150 milligrams (mg) every 12 hours, but if the patient’s creatinine clearance was 15-30 ml/min the dose should be 75mg every 12 hours.
  • In acute Venous ThromboEmbolism (VTE), it should be started after 5-10 days of Low Molecular Weight Heparin (LMWH), the dose will be 150mg every 12 hours.

6. Monitoring tests for Dabigatran:

  • Thrombin Time (TT): is used to look for theĀ residualĀ drug.
  • Dilute thrombin time: used to look for the residual drug and/or to assess the extent of the anticoagulant effect.


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