3 Vorinostat Lecture Notes For Healthcare Professionals

 

1. It is a histone deacetylase inhibitor.



2. Indications:

  1. Cutaneous T cell lymphoma.


3. Mechanism of action:

It leads to the re-expression of genes that are previously silenced in cutaneous T cell lymphoma, those re-expressed genes encode transcription factors which promote T cell differentiation instead of proliferation leading to tumor regression.



 

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