3 Vorinostat Lecture Notes For Healthcare Professionals


1. It is a histone deacetylase inhibitor.

2. Indications:

  1. Cutaneous T cell lymphoma.

3. Mechanism of action:

It leads to the re-expression of genes that are previously silenced in cutaneous T cell lymphoma, those re-expressed genes encode transcription factors which promote T cell differentiation instead of proliferation leading to tumor regression.


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